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KMID : 1004820130140030177
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Journal of Biomedical Research
2013 Volume.14 No. 3 p.177 ~ p.179
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Case of Sporadic T-cell Lymphosarcoma in Cattle
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Yang Joon-Young
Jeong Da-Hee
Min Chang-Woo
Kang Kyung-Ku
Kim Ah-Young
Lee Eun-Mi
Lee Eun-Joo
Lee Myeong-Mi
Kim Sang-Hyeob
Sung Soo-Eun
Jeong Kyu-Shik
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Abstract
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We would like to report a case of bovine lymphosarcoma.Parous cattle from a livestock farmhouse were examined formutinodular masses in the abdominal cavity after slaughter.For clinical signs, animals presented mild leukemic signsbut did not have viral or bacterial infection. Grossly, whitishto yellowish smooth masses similar to fat tissue were coveredwith a thin membrane. A multilobulated mass formedaround the arteri, and there was a large quantity of reddishfluid on the cut surface. Histopathologically, a monomorphicpopulation of lymphocytes was observed along withsmall amounts of cytoplasm, round nuclei with coarselygranular chromatin, and numerous mitotic figures in thesamples. In the tumor lesion, uniformly round cells hadinvaded with abundant neovascularization. Especially, theimmunohistochemical phenotype of tumor cells was positivefor anti-CD3 and negative for anti-CD8 and anti-CD20.Therefore, morphological analysis diagnosed the mass as amultinodular bovine lymphosarcoma of T-cell origin withoutany sign of infection by a viral agent.
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KEYWORD
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lymphosarcoma, SBL, bovine, T-cell
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